By subjecting a large number of proteins of this parasite antibodies naturally produced by the immune system of infected children in Kenya, scientists have identified antigens previously unknown.
They also found new ways to use these antigens, which cause an immune reaction, involving them in vaccine to enhance protection.
Face resistance to antimalarial treatment.
” The antimalarial drug resistance is a growing problem that makes it necessary to develop vaccines to combat Plasmodium falciparum before it makes sick people infected,” said Dr. Faith Osier, of Institute Kenya Medical Research, lead author of the study published in the journal Science Translational Medicine.
She said the study ” Provides a large number of new vaccine candidates that offer real hope “.
Malaria is responsible for over 600,000 deaths per year worldwide, mostly young children in sub -Saharan Africa.
Identify ways natural protection for some children.
The researchers followed more than six months, a group of children carrying malaria parasites.
Some have developed the disease, while others were protected by natural antibodies that prevented pests from entering their blood cells and saved severe symptoms.
Blood samples they have identified antibody combinations may confer complete protection against malaria, said these researchers.
“Clinical trials of anti- malarial vaccines focused in the past on a single target and had limited success, ” said Dr. Julian Rayner of the Sanger Institute in the UK, one of the authors of the study.
“With this approach, we can systematically test a greater number of targets as well as combinations of targets,” he says.
Apart from the growing resistance to antimalarial drugs, mosquitoes are less affected by insecticides.