Ludwik Leibler laboratory ” Soft Matter and Chemistry” and Didier Letourneur, laboratory translational vascular research, have developed an original method of bonding based on nanoparticles contained in a solution.
The principle spread this solution on surfaces paste to link the nanoparticles to the tissue molecular network and allow the formation of connections between the two surfaces.
A priori extremely simple, this method of bonding is a revolution in the biological world no satisfactory solution had been allowed to stick tissues together.
It was necessary to overcome the obstacle conferred by the nature of the tissues, near that of gels, liquid, soft, slippery, very difficult to to join them.
Tested on deep wounds of rats, the aqueous solution of nanoparticles without chemical reaction, put thirty seconds act.
compared to the traditional method of stitches, she has demonstrated a simple use and efficiency remarkable, allowing rapid healing without inflammation or necrosis, to its almost complete disappearance.
Beyond skin, the nanoparticle solution can also help repair organs ” Soft ” such as the liver, spleen or lung, difficult to suture because they tear the passage of the needle, the researchers said in a statement Inserm.
These have tested rats with a deep gash in their liver or lobe severed, causing heavy bleeding : applied to the edges of the wound, which then e ty pressed against each other, the solution has a few seconds to stop the bleeding and thereby preserve the body.
But for researchers, the applications of this solution does not stop there.
They plan – after having experienced successfully on the heart – set of medical devices organs or tissues, to therapeutic purposes or mechanical repair and reinforcement, they specify.
It is safe bet this French discovery should allow the era of regenerative medicine to gain a new momentum.
Angewandte Chemie, published online April 16, 2014.