Oct

30

Category: Health | Date : October 30, 2014

In France, h & eacute; mopathies or malignant blood cancers represented & eacute; & egrave feel 6 ; me cause cancer, with 35,000 cases per year.

These blood cancers include many diseases that have some commonalities.

Among these diseases, leuc & eacute; mie lympho & iuml ; chronic and lymphoma & agrave ; mantle cell forms are little fr & eacute; but quent aggressive h & eacute; malignant mopathies.

LLC, a fr & eacute; increased frequency of relapses and r & eacute; resistances to treatment.

Although leuc & eacute; mie lympho & iuml ; a chronic disease that is & eacute; g & eacute evolves in n & eacute; ral slowly, with an average survival of 18 months & agrave ; 10 years depending on the stage of the disease, relapse and r & eacute; resistances to treatment are increasingly fr & eacute; quent with time.

Pr forms & eacute; feeling a d & eacute; l & eacute; ing 17p and TP53 mutation are aggressive forms because these conditions cause your icirc ; NEET loss of g & egrave ; not tr & egrave ; s important TP53, which dé detects the pr & eacute; sence tumor cells and d & eacute; latch the death of these cells.

This m & ecirc ; g & egrave me, do help & agrave ; tumor suppression during chimioth & eacute; therapy.

But with time, del 17p and TP53 mutation are more fr & eacute; quent which came & icirc, not a relapse or a r & eacute; sistance treating chimioth & eacute; therapy, the disease is becoming more and more aggressive.

Lymphoma & agrave ; Mantle cell is a rare disease occurring more particularly & egrave ; larly men & acirc ; g & eacute; s 65 years on average.

It is a disease with a poor prognosis with a mean overall survival of 1 & agrave ; 2 years after & egrave ; s & egrave Premi ; re relapse.

A th & eacute; & eacute therapy CIBL e new class.

The Ibrutinib, developed by Janssen- Cilag International and Pharmacyclics is the first tyrosine kinase inhibitor of Burton, and is the Premi & egrave ; re th & eacute; therapy CIBL & eacute; e against CLL and MCL administered & eacute; e in monoth & eacute; therapy by orally once daily.

This m & eacute; dicament acts by binding & agrave ; BTK enzyme, which like idiots & eacute; frequency blocking the transmission of survival signals in malignant B cells.

By blocking this prot & eacute; ine BTK, Imbruvica & reg; help & agrave ; and remove & agrave ; r & eacute; reduce the number of cells canc & eacute; ous and that & agrave ; slow the d & eacute; development of cancer.

The treatment of adult patients with leuc & eacute; mie lympho & iuml ; chronic with re & ccedil ; u at least one ant treatment & eacute; laughing, or Premi & egrave ; re online if d & eacute; l & eacute; ing 17p or TP53 mutation patients in whom an immune chimioth & eacute; & eacute inadapt therapy is e.

The treatment of adult patients with lymphoma & agrave ; relapsed mantle cell or r & eacute; refractory.

Imbruvica & reg; repr & eacute; feel a new hope for patients fulfilling the conditions for the given indication as & eacute; es efficiency & eacute; show for the LLC, an am & eacute; significant improvement in survival after disease progression & egrave without ; s 9.4 months of treatment.

These r & eacute; results are significantly sup & eacute; line laughing compared to patients & eacute; s with ofatumumab.

As for the LCM, a rate of r & eacute; response 68% a & eacute; t & eacute; observed & eacute; patients r & eacute; refractories with a hard & eacute; e m & eacute; diane progression-free survival of 13.9 months without.

This dé study did not include a comparison with other treatment.

Finally, on the tol & eacute; ance, the most common side effects fr & eacute; quent & eacute; were the diarrhea & eacute; e, musculoskeletal pain, respiratory infection sup & eacute; EXTERIOR, redness, nausea & eacute; es and fi & egrave ; vre and decreased neutrophil and constipation.

Less fr & eacute; quently have & eacute; t & eacute; observed & eacute; s a year & eacute; mie, pneumonia and decreased platelet.

In France, Ibrutinib is available from April 2014 as part of a temporary authorization for use in the cohort and the LCM LLC.

More than 300 patients are treated & eacute; s in the indication of the MA European & eacute; enne.

Source: Communiqu & eacute; Press laboratory Janssen October 17, 2014: & quot; The Ibrutinib, breakthrough innovation in the treatment of two types of blood cancers obtained an MA European & eacute; enne & quot ;.

Oct

30

Category: Health | Date : October 30, 2014

R & eacute; invent the solidarity & eacute; at the municipal level.

In this town of 8,000 inhabitants near Clermont- Ferrand, in the foothills of the plateau Gergovie id & eacute; ea germ & eacute; at last & egrave ; res & eacute; municipal elections, drawing the complete & eacute; n & eacute commentary ; GOCI & eacute; e by the town of Caumont-sur-Durance September 2013.

End of 2012, they & eacute; & agrave were 3.3 million ; in & ecirc ; be dé filled, against 2.8 million two years before, according to the mutuality & eacute; Fran & ccedil ; ease.

A trend in & eacute; called from ann & eacute; es 70.

Once & eacute; read the new & eacute; & eacute a municipal team, won & eacute; demand and s & eacute; & eacute ;, lectionn among three offers mutual r & eacute; gional, Precocia to offer rates n & eacute; GOCI & eacute; s.

Unlike Caumont-sur-Durance, which offers adh & eacute; & agrave single mission ; 47 euros, the & quot; Romagnatoise & quot; offers three levels of service, depending on the & acirc ; ge, 20 & agrave ; 85 euros per month.

The target ? & quot; The administered & eacute; s and Salari & eacute; s & agrave working ; Romagnat who are just above the minimum required to access social & eacute; der & agrave ; CMU and assistance & agrave ; the acquisition of a complete & eacute; ing commentary & eacute; & quot ;, says Assistant Social Affairs, Marie- Jeanne Gilbert.

& quot; We esp & eacute; that this offer would be targeted at most d & eacute; but they carry are not aware of these initiatives.

We must get them.

Our adh & eacute; ent often have low wages and small pensions and want r & eacute; reduce the maximum co & ucirc ; t their compl & eacute; commentary & quot ;, stressed that m & eacute; doctor g & eacute; n & eacute; realistic & agrave ; retirement.

The excitement is waiting for you : in three weeks, a total of 150 common adh & eacute; sions.

Many people who come to look, Figures & agrave ; support their current benefits & agrave ; About those & eacute; es by the municipality & eacute;.

Up & agrave ; 700 euros of dé savings per year.

& quot; This is an initiative all & agrave ; is sensational & quot ;, Andr & eacute enthuses e Otavy, trembling on his cane, after & egrave ; s seeing a counselor mutual & agrave ; City Hall.

This withdrawal & eacute; e of 86 years will be able to & eacute; conomiser 60 euros per month: & quot; These are my children going & ecirc ; be happy & quot; !

& quot; This is a succ & egrave ; s because people find benefit levels sup & eacute; laughing & agrave ; they have a more comp price & eacute; titif & quot ;, says Marie -Jeanne Gilbert.

Up & agrave ; 700 euros less per year for individual subscriptions, according to her.

G & eacute; raldine Kalsron has adh & eacute; rer all his household, m & ecirc ; if she does & eacute; conomise 10 euros per month, & quot; Because it is always & ccedil ; a & quot ;, says this m & egrave ; re two children down & acirc ; ge.

Dental assistant, she will soon OCIRC & ; t subscribe & agrave ; mutual mandatory, his employer, but do not give much for the & quot; & quot ;: Romagnatoise & quot; My head told me d & eacute; j & agrave ; said that the future of mutual work would offer only basic services, m & ecirc ; me Dental.

So, I take in the over- complete & eacute; commentary for ecirc & ; s & ucirc be ; er ‘& ecirc, be well assured & eacute; e & quot;.

The initiative of Vaucluse made ​​small four corners of France.

& quot; This is the surrender to go & ucirc ; t day of a concept, that of small mutual village, autonomous, who disappeared in the wave of mergers occurred after & egrave ; s implementation of the new code of mutuality & eacute; 2003 & quot ;, says Jean -Louis Span pr & eacute; president of the Association diversity & eacute; and proximity & eacute; mutual.

The opportunity also for the Town of & quot; r & eacute; invent a solidarity & eacute; of proximity & eacute; & quot;.

Precocia sales manager, Fabien Paulet sees him & quot; Syst & egrave ; me win-win & quot; for mutual and assured & eacute; s.

When they have acc & egrave ; s & agrave ; of & quot; quality & Benefits eacute; & agrave ; Unbeatable Prices & quot ;, mutual r & eacute; gional, which operate much the mouth- & agrave ; -oreille, gaining notoriety & eacute; t & eacute ;: Precocia account increase by 10% the number of adh & eacute; ent.

Sollicit & eacute; e & agrave by 250 ; 300 municipality & eacute; s, Assistant & agrave ; Originally the project Caumont-sur-Durance has also Mount & eacute; a & quot; consulting firm & quot; to help & agrave ; launch.